Positions：
Phone：86-731-84619709
Fax：86-731-84612685
E-mail：cychen@isa.ac.cn
Employment History
09/2009- Principle Investigator at Institute of Subtropical Agriculture, Chinese Academy of Sciences
11/2005- 08/2009 Postdoctoral Fellow in Plant Science Department, University of Kentucky
07/1994- 08/1998 Lecturer at Xuan’en normal school, Hubei province.
Education:
Ph.D. Genetics (2005), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
M.S. Plant Science (2001), Life Science Department, Hunan Agricultural University
B. S. Biology (1994), Biology Department, Xiaogan University
Research interests: Rice ionomics.
Rice is a staple crop that accumulates more cadmium (Cd) in the grain than do other cereal crops. With increasing soil Cd pollution, it is necessary to lower grain Cd levels for food safety and to increase Cd-resistance for the purposes of phytoremediation. At present, a limited number of genes have been identified that are responsible for Cd uptake, translocation, compartmentalization, or sequestration, and this is a prerequisite for genetic improvement of Cd accumulation and resistance. Our research is focused on identifying novel genetic elements involved in Cd accumulation and detoxification in rice. We are employing forward genetic tools to uncover the molecular mechanisms underlying the natural variation present in diverse rice germplasm, and we use reverse genetic tools to identify genes that function in Cd transport.
In addition, the importance of nutritional microelements in rice, such as iron (Fe), zinc (Zn), and manganese (Mn) has been well recognized. Thus, we are also interested in developing new molecular markers to map and clone the genes that control the accumulation of these mineral elements in the rice grain, and to utilize these markers in rice breeding.
The ultimate goal of our research is rice that has a high nutrition value and is Cd free.
Li, L., Mao, D., Sun, L., Wang, R., Tan, L., Zhu, Y., Huang, H., Peng, C., Zhao, Y., Wang, J., Huang, D. and Chen, C#. 2022. CF1 reduces grain-Cd levels in rice (Oryza sativa). Plant J. https://doi.org/10.1111/tpj.15736.
Mao, D*., Tao, S*., Li, X*., Gao, D., Tang, M., Liu, C., Wu, D., Bai, L., He, Z., Wang, X., Yang, L., Zhu, Y., Zhang, D#., Zhang, W#. and Chen, C#. 2022. The Harbinger transposon-derived gene PANDA epigenetically coordinates panicle number and grain size in rice. Plant Biotechnol. J. https://doi.org/10.1111/pbi.13799.
Ma X, Feng Y, Yang Y, Li X, Shi Y, Tao S, Cheng X, Huang J, Wang XE, Chen C, Monchaud D, Zhang W#. Genome-wide characterization of i-motifs and their potential roles in the stability and evolution of transposable elements in rice. Nucleic Acids Res. 2022 Feb 21:gkac121. doi: 10.1093/nar/gkac121.
Sun L*, Wang R*, Tang W*, Chen Y*, Zhou J, Ma H, Li S, Deng H, Han L, Chen Y, Tan Y, Zhu Y, Lin D, Zhu Q, Wang J, Huang D, Chen C#. 2022. Robust identification of low-Cd rice varieties by boosting the genotypic effect of grain Cd accumulation in combination with marker-assisted selection. J Hazard Mater. 424(Pt D):127703. doi: 10.1016/j.jhazmat.2021.127703. Epub 2021 Nov 6. PMID: 34799159.
Zhou Z, Sun L, Hu W, Zhou B, Tao S, Zhang S, Lv Y, Zhao Z#, Chen C#.2021 Breeding High-Grain Quality and Blast Resistant Rice Variety Using Combination of Traditional Breeding and Marker-Assisted Selection. RICE SCI. 28 (5): 422-426 DOI:10.1016/j.rsci.2021.07.002.
Feng Y, Tao S, Zhang P, Sperti FR, Liu G, Cheng X, Zhang T, Yu H, Wang XE, Chen C, Monchaud D, Zhang W#. 2022. Epigenomic features of DNA G-quadruplexes and their roles in regulating rice gene transcription. Plant Physiol. 188(3):1632-1648. doi: 10.1093/plphys/kiab566.
Tang L, Dong J, Tan L, Ji Z, Li Y, Sun Y, Chen C, Lv Q, Mao B, Hu Y, Zhao B#. 2021. Overexpression of OsLCT2, a Low-Affinity Cation Transporter Gene, Reduces Cadmium Accumulation in Shoots and Grains of Rice. Rice (N Y). 14(1):89. doi: 10.1186/s12284-021-00530-8.
Li X, Xiang F, Zhang W, Yan J, Li X, Zhong M, Yang P, Chen C, Liu X, Mao D, Zhao X. 2021. Characterization and fine mapping of a new dwarf mutant in Brassica napus. BMC Plant Biol. 21(1):117. doi: 10.1186/s12870-021-02885-y.
Liu T, Sun L, Meng Q, Yu J, Weng L, Li J, Deng L, Zhu Q, Gu X, Chen C, Teng S & Xiao, G. (2021). Phenotypic and genetic dissection of cadmium accumulation in roots, nodes and grains of rice hybrids. Plant and Soil, 463(1), 39-53. DOI: https://doi.org/10.1007/s11104-021-04877-1.
Tan L, Qu M, Zhu Y, Peng C, Wang J, Gao D & Chen C#. 2020. The OsZIP5 and OsZIP9 transporters function synergistically in Zn/Cd uptake in rice. Plant Physiol. 183(3):1235-1249. DOI: 10.1104/pp.19.01569.
Tan Y, Sun L, Song Q, Mao D, Zhou J, Jiang Y, Wang J, Fan T, Zhu Q, Huang D, Xiao H, Chen C#. 2020. Genetic architecture of subspecies divergence in trace mineral accumulation and elemental correlations in the rice grain. Theor Appl Genet. 133(2):529-545. doi: 10.1007/s00122-019-03485-z.
Fang Y*, Chen L*, Lin K, Feng Y, Zhang P, Pan X, Sanders J, Wu Y, Wang X, Su Z, Chen C, Wei H#, Zhang W#. 2019. Characterization of functional relationships of R-loops with gene transcription and epigenetic modifications in rice. Genome Res. 29(8):1287-1297. doi: 10.1101/gr.246009.118
Yan H*, Xu W*, Xie J*, Gao Y, Wu L, Sun L, Feng L, Chen X, Zhang T, Dai C, Li T, Lin X, Zhang Z, Wang X, Li F, Zhu X, Li J, Li Z, Chen C, Ma M, Zhang H#, He Z#. 2019. Variation of a major facilitator superfamily gene contributes to differential cadmium accumulation between rice subspecies. Nat Commun. 10(1):2562. doi: 10.1038/s41467-019-10544-y.
Tan L, Zhu Y, Fan T, Peng C, Wang J, Sun L#, Chen C. 2019. OsZIP7 functions in xylem loading in roots and inter-vascular transfer in nodes to deliver Zn/Cd to grain in rice. Biochem Biophys Res Commun. 512(1):112-118. doi: 10.1016/j.bbrc.2019.03.024.
Mao D*, Xin Y*, Tan Y, Hu X, Bai J, Liu ZY, Yu Y, Li L, Peng C, Fan T, Zhu Y, Guo YL, Wang S, Lu D, Xing Y, Yuan L#, Chen C#. 2019. Natural variation in the HAN1 gene confers chilling tolerance in rice and allowed adaptation to a temperate climate.Proc Natl Acad Sci U S A. 116(9):3494-3501. doi: 10.1073/pnas.1819769116.
Tang L, Mao B, Li Y, Lv Q, Zhang L, Chen C, He H, Wang W, Zeng X, Shao Y, Pan Y, Hu Y, Peng Y, Fu X, Li H#, Xia S#, Zhao B#. 2017. Knockout of OsNramp5 using the CRISPR/Cas9 system produces low Cd-accumulating indica rice without compromising yield. Sci Rep. 7(1):14438. doi: 10.1038/s41598-017-14832-9.
Tang, M., Zhou, C., Meng, L., Mao, D., Liu, C., Peng, C., Zhu, Y., Zhang, D., Huang, D., Tan, Z., Chen, C#. 2016. Overexpression of OsSPL9 enhances accumulation of Cu in rice grain and improves its digestibility and metabolism, Journal of Genetics and Genomics. 43(11): 673. DOI: 10.1016/j.jgg.2016.09.004.
Li D*, Huang Z*, Song S*#, Xin Y*#, Mao D*, Lv Q*, Zhou M, Tian D, Tang M, Wu Q, Liu X, Chen T, Song X, Fu X, Zhao B, Liang C, Li A, Liu G, Li S, Hu S, Cao X, Yu J, Yuan L#, Chen C#, Zhu L#. 2016. Integrated analysis of phenome, genome, and transcriptome of hybrid rice uncovered multiple heterosis-related loci for yield increase. Proc Natl Acad Sci USA. 113(41): E6026–E6035. DOI: 10.1073/pnas.1610115113.
Sun L, Xu X, Jiang Y, Zhu Q, Yang F, Zhou J, Yang Y, Huang Z, Li A, Chen L, Tang W, Zhang G, Wang J, Xiao G, Huang D, Chen C#. 2016. Genetic Diversity, Rather than Cultivar Type, Determines Relative Grain Cd Accumulation in Hybrid Rice. Front Plant Sci. 7:1407. DOI:10.3389/fpls.2016.01407.
Mao D*, Yu L*, Chen D, Li L, Zhu Y, Xiao Y, Zhang D, Chen C#. 2015. Multiple cold resistance loci confer the high cold tolerance adaptation of Dongxiang wild rice (Oryza rufipogon) to its high-latitude habitat. Theor Appl Genet. 128:1359–1371. DOI: 10.1007/s00122-015-2511-3.
Liu L*, He X*, Wang K, Xie Y, Xie Q, O'Donnell A, Chen C#. 2015. The Bradyrhizobium-legume symbiosis is dominant in the shrubby ecosystem of the Karst region, Southwest China. European Journal of Soil Biology. 68: 1-8. DOI:10.1016/j.ejsobi.2015.02.004.
Hu Y, Wu S, Sun Y, Li T, Zhang X, Chen C, Lin G, Chen B. 2015. Arbuscular mycorrhizal symbiosis can mitigate the negative effects of night warming on physiological traits of Medicago truncatula L. Mycorrhiza. 25(2):131-42. DOI: 10.1007/s00572-014-0595-2.
Yao W*, Sun L *, Zhou Hao, Yang Fei, Mao D, Wang J, Chen L, Zhang G, Dai J, Xiao G& Chen C#. 2015. Additive, dominant parental effects control the inheritance of grain cadmium accumulation in hybrid rice. Molecular Breeding. 35:39. DOI: 10.1007/s11032-015-0246-0.
Tang M*，Mao D*，Xu L，Li D，Song S， Chen C #. 2014. Integrated analysis of miRNA and mRNA expression profiles in response to Cd exposure in rice seedlings. BMC Genomics. 15: 835. DOI: 10.1186/1471-2164-15-835..
Yang C*, Li D*, Liu X, Ji C, Hao L, Zhao X, Li X, Chen C, Cheng Z, Zhu L. 2014. OsMYB103L, an R2R3-MYB transcription factor, influences leaf rolling and mechanical strength in rice (Oryza sativa L.). BMC Plant Biol. 14:158. DOI: 10.1186/1471-2229-14-158.
Liu W, Zhang D#, Tang M, Li D, Zhu Y, Zhu L, Chen C#. 2013. THIS1 is a putative lipase that regulates tillering, plant height and spikelet fertility in rice. J EXP BOT. 64（14）：4389-402. DOI: 10.1093/jxb/ert256.
Yang C*, Li D*, Mao D, Liu X, Ji C, Li X, Zhao X, Cheng Z, Chen C, Zhu L. 2013. Overexpression of microRNA319 impacts leaf morphogenesis and leads to enhanced cold tolerance in rice (Oryza sativa L.). Plant Cell Environ. 36(12): 2207-18. DOI: 10.1111/pce. 12130.
Chen C, Zhu H. 2013. Are common symbiosis genes required for endophytic rice-rhizobial interactions? Plant Signaling & Behavior. 8:e25453. DOI: 10.4161/psb.25453.
Yuan H, Ge T, Chen C, O'Donnell AG, Wu J. 2012. Significant role for microbial autotrophy in the sequestration of soil carbon. Appl Environ Microbiol. 78(7): 2328-36. DOI: 10.1128/AEM.06881-11.
Mao D, Chen C#. 2012. Colinearity and similar expression pattern of rice DREB1s reveal their functional conservation in the cold-responsive pathway. PLoS ONE. 7(10): e47275. doi: 10.1371/journal.pone.0047275.
Wang A, Tang J, Li D, Chen C, Zhao X, Zhu L. 2009. Isolation and functional analysis of LiYAB1, a YABBY family gene, from lily (Lilium longiflorum). J Plant Physiol. 166(9):988-95. DOI:10.1016/j.jplph.2008.11.011.
Chen C, Zou J, Zhang S, Zaitlin D, Zhu L. 2009. Strigolactones are a newly-defined class of plant hormones that inhibit shoot branching and mediate the interaction of plant-AM fungi and plant-parasitic weeds. Sci China C Life Sci. 52: 693-700. DOI: 10.1007/s11427-009-0104-6.
Chen C, Fan C, Gao M, Zhu H. 2009. Antiquity of CASTOR and POLLUX, the twin ion channel-encoding genes key to the evolution of root symbiosis in plants. Plant Physiol. 149:306-17. Doi: 10.1104/pp.108.131540.
Chen C, Ané, J, Zhu H. 2008. OsIPD3, an ortholog of the medicago truncatula DMI3 interacting protein IPD3, is required for mycorrhizal symbiosis in rice. New Phytologist. 180(2): 311-15. DOI: 10.1111/j.1469-8137.2008.02612.x.
Chen C, Gao M, Liu J, Zhu H. 2007. Fungal symbiosis in rice requires an ortholog of a legume common symbiosis gene encoding a Ca2+/calmodulin-dependent protein kinase. Plant Physiol. 145(4):1619-28. DOI:10.1104/pp.107.109876.
Chen C*, Xiao H*, Zhang W, Wang A, Xia Z, Li X, Zhai W, Cheng Z, Zhu L. 2006. Adapting rice anther culture to gene transformation and RNA interference. Sci China C Life Sci. 49 (5): 414-28. DOI: 10.1007/s11427-006-2013-2.
Zhai W, Chen C, Zhu X, Chen X, Zhang D, Li X, Zhu L. 2004. Analysis of T-DNA- Xa21 loci and bacterial blight resistance effects of the transgene Xa21 in transgenic rice. Theor Appl Genet. 109(3):534-42. DOI: 10.1007/s00122-004-1670-4.
*: these authors contributed equally. #: Author for correspondence.
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