Professor
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Yulong Yin
Yulong Yin　/　Professor

E-mail：yinyulong@isa.ac.cn
Phone：(86)-731-84619703
Fax：(86)-731-84612685

Resume

Yulong Yin is a Professor, Institute Faculty Fellow in the Research Center of Animal Healthy Feeding and cross-Appointments with the Life Science College of Nanchang University. He earned his bachelor's degree in Biology from Hunan Normal University Changsha, Hunan, China, a master's degree in animal nutrition from Agricultural University of Central China Wuhan, China, and a doctorate (Animal Nutrition) from The Queen's University of Belfast, UK.

He conducts research in Animal Production; Animal Feed, Nutrition and Physiology of Amino Acids and Protein; Gene Expression and Gene Therapy, Comparative Animal Nutrition, Growth and Development of Animals, Biology and Pathobiology of Nitric Oxide and Polyamines; Diabetes, Obesity and Cardiovascular Complications, Fetal Nutrition and Metabolism, Animal Models of Human Diseases, Nutritional Biochemistry and Physiology.

He has received several prestigious awards as follows,
1.the Chinese Academy of Sciences, May, 2000
2. National Science and Technology Progress Prize of China, 2008 (as project leader and the first researcher) “Applied Techniques of Regulating Nitrogen and Phosphorus Metabolism in Livestock and Poultry and Safety Feed Production”
3.National Science and Technology Progress Prize of China, December 1996 (as project leader  and the first researcher) “Ileal digestibility of nutrients and ileal digestible essential amino acid requirements for growing-finishing pigs”
4. National Science and Technology Progress Prize of China, December, 1997 (as main researcher)-“Swine and poultry nutritional parameter”
5.Max-planck Gesellschaft Scholarship, Germany, June 21, 1995
6.Science and Technology Progress Prize of Hunan Province, December 1994 (as project leader and the second researcher)-”Utilization of the Chinese Maifanite stone as a mineral and trace elements for animals”
7.Outstanding Scientist Prize of the Chinese Government, October 1, 1992
8. Young Scientist Prize of Agricultural Association of Hunan Province, March 1, 1992
9.Young Scientist Prize of Chinese Association of Agriculture, April 7, 1992
10.Young Scientist Prize of the Chinese Academy of Sciences, October 17, 1991
11.Science and Technology Progress Prize of the Chinese Academy of Sciences, December 1990 (as main researcher)-“Research of the animal feedstuff and animal production in Taoyuan County” 
12. Max-planck Gesellschaft Scholarship, West Germany, December 31, 1985

Current project

Full Professor and Director of the  Animal Nutrition and Health Center (Institute of Subtropical Agriculture, The Chinese Academy of Sciences)                                                                                                     1999 – Present
Research project
1. Evaluation of galactomanan and Chinese herb extraction (tea polyphenols and essential oils) as an alternative to dietary antibiotics to control food-borne pathogens in livestock
2. Nutritional and health function of carbohydrate for animal and human
3. Amino acids and sugar flu between animal organ and tissues

Research Associate
Dept. of Animal and Poultry Science       
University of Guelph, Canada           Nov. 1999 - 2001
Research project:
Effect of small intestinal microflora fermentation on nutrient digestion and absorption and threonine and lysine requirements      

Research Associate
USA Department of Agriculture, U.S. Meat Animal Research Center, Clay Center, NE 68933, USA                                                              Dec. 1999 - May 2000
Research project:
Effect of endogenous amino acid losses on visceral organ size and energy and amino acid metabolism in growing pigs 

Postdoctoral Research
Dept. of Animal Science       
The University of Manitoba, Canada    Oct. 1997 - Oct.1999
Research project:       
1. Improvement of the nutritive value of hulless barley and peas for swine and poultry by feed enzyme addition (granted by Finnfeeds International Ltd. UK).
2. Studied the effects of micronization and feed enzyme treatments of hulless barley and peas on nutrient utilization for starter, grower and finisher pigs and broiler.
3. Studied the effects of heat treating grains and peas on phytase activity and apparent digestibility of phosphorus, calcium, energy and amino acids in pigs and poultry.
 
PhD Research
The Queen's University of Belfast, UK  Nov.1994 - Aug. 1997
Research project:
1. Effects of exogenous enzyme and antibiotic supplementation with grains on nutrient utilization in pigs.
2. Assessed the effects of dietary non-starch polysaccharides (NSP) levels exogenous enzyme on growth performance, ileal endogenous nitrogen and amino acids losses, and energy and amino acid utilization in  pigs.
3. Assessed the effects of exogenous enzyme on ileal and fecal digestibility of amino acids, energy and NSP of pigs fed on diets with and without antibiotic supplementation

Visiting Professor
Ern？hrungsphysiologie “Oskar Kellner”, Forschungsinstitüt für die Biologie landwirtschaftlich Nutztiere, Rostock, Germany         Nov.1995- April 1996
Research project:
Determination of the true amino acid digestibility with 15N dilution techniques

Full Professor and Director of the Dept. Animal Nutrition
The Chinese Academy of Sciences, Changsha Institute of
Agricultural Modernization (CAS-CIAM), China April 1994 – October 1994
Research and industry-based projects:
1. Relative bioavailability and growth performance of copper in a copper-lysine complex or copper sulfate for growing pigs
2. Promoting and selling the feedstuff products of Hunan 3A Feedstuff Company

Associate Professor
CAS-CIAM, China     Jan. 1991 - March 1994

Research and industry-based projects:
1.Creating and chairing  Hunan 3A Feeds and Pork Company and developing  techniques of manufacturing the 3A mineral premixes, vitamins premixes and feed concentrates for pigs and poultry
2.Evaluating different techniques for determining the ileal digestibility of protein and amino acids, including: ileal simple T cannula, ileo-caecal re-entrant cannulae, ileo-rectal anastomsis, ileo-caecal valve T-caecal cannula (PVTC) and ileal mobile nylon bag technique
3.Determining ileal and fecal digestibility of energy, cell wall constituents, crude protein and amino acids in 65 kinds of feedstuffs and mixed diets for pigs
4.Measuring the ileal digestible essential amino acid requirement for growing pigs
5.Utilization of the Changsha Maifanite stone as mineral and trace elements additive for animals
6.Utilization of oil seed meals as the main protein feedstuffs for swine and poultry

Assistant Professor
CAS-CIAM, China     Nov.1987 - Dec. 1990

Research projects:
1. Studied the nutritive values of raw and ammonium treated rape seed meals for animals
2.Use of Chinese Maifanite stone as a trace element for pigs and chicken
3.Studied the nutritive value and anti-nutritional factors of raw and heat treated soybean, field bean and pea for pigs

Research Assistant
CAS-CIAM, China      Jan. 1983 - Dec.1985

Article

  1. GABA transporter sustains IL-1 beta production in macrophages / Xia, YY (Xia, Yaoyao); He, F (He, Fang); Wu, XY (Wu, Xiaoyan); Tan, B (Tan, Bie); Chen, SY (Chen, Siyuan); Liao, YX (Liao, Yuexia); Qi, M (Qi, Ming); Chen, S (Chen, Shuai); Peng, YY (Peng, Yuanyi);Yin, YL (Yin, Yulong); Ren, WK (Ren, Wenkai) / SCIENCE ADVANCES 7(15): eabe9274 DOI: 10.1126/sciadv.abe9274 / APR 2021
  2. Yuexia Liao, Lijuan Fan, Peng Bin, Congrui Zhu, Qingyi Chen, Yepeng Cai, Jielin Duan, Qian Cai, Wei Han, Shizhen Ding, Xiangyu Hu,Yiran Zhang, Yulong Yin, Wenkai Ren. GABA signaling enforces intestinal germinal center B cell differentiation. PNAS，2022，Vol 119 DOI:10.1073/pnas.221592119 
  3. Natural Products from Mammalian Gut Microbiota / Wang, LL (Wang, Leli); Ravichandran, V (Ravichandran, Vinothkannan); Yin, YL(Yin, Yulong); Yin, J (Yin, Jia); Zhang, YM (Zhang, Youming) / CellPress：TRENDS IN BIOTECHNOLOGY37(5): 492-504 DOI: 10.1016/j.tibtech.2018.10.003 / MAY 2019 
  4. Echinacea purpurea-derived homogeneous polysaccharide exerts anti-tumor efficacy via facilitating M1 macrophage polarization/Wenkai Ren, Junfeng Ban, Yaoyao Xia, Fang Zhou, Caihong Yuan, Huanhuan Jia, Hailan Huang, Mingmin Jiang, Minjian Liang, Zhaodong Li, Youyong Yuan, Yulong Yin, and Hong Wu (http://creativecommons.org/licenses/by-nc-nd/4.0. The Innovation4(2), 100391 
  5. China’s low-emission pathways toward climate-neutral livestock production for animal-derived foods. Rong Wang, Zhaohai Bai, Jinfeng Chang, Qiushuang Li, Alexander N. Hristov, Pete Smith, Yulong Yin, Zhiliang Tan, and Min Wang. 2022; https://doi.org/10.1016/j.xinn.2022.10022，The Innovation3(2), 100220
  6. Leucine in Obesity: Therapeutic Prospects / Yao, K (Yao, Kang); Duan, YH (Duan, Yehui); Li, FN (Li, Fengna); Tan, B (Tan, Bie); Hou, YQ (Hou, Yongqing); Wu, GY (Wu, Guoyao); Yin, YL (Yin, Yulong) / CellPress：TRENDS IN PHARMACOLOGICAL SCIENCES 37(8): 714-727 DOI: 10.1016/j.tips.2016.05.004 / AUG 2016
  7. Wang L., Zhang Y., Xu J., et al., (2023). Listening to enteric bacteria from the perspective of antibiotic alternatives in animal husbandry. The Innovation Life 1(2), 100022. https://doi.org/10.59717/j.xinn-life.2023.100022
  8. Yin Jie,Li Yunxia,Tian Yu,Zhou Feng,Ma Jie,Xia Siting... & Huang Xingguo.(2023).Obese Ningxiang pig-derived microbiota rewires carnitine metabolism to promote muscle fatty acid deposition in lean DLY pigs. The Innovation (5). doi:10.1016/J.XINN.2023.100486.
  9. Chen Shujie,Zhang Puxuan,Duan Huimin,Wang Jie,Qiu Yuyueyang,Cui Zongbin... & Xie Liwei.(2023).Gut microbiota in muscular atrophy development, progression, and treatment: New therapeutic targets and opportunities. The Innovation (5). doi:10.1016/J.XINN.2023.100479.
  10. Tian Junquan,Li Yuying,Bao Xuetai,Yang Fan,Tang Xiongzhuo,Jiang Qian... & Yao Kang.(2023).Early weaning causes small intestinal atrophy by inhibiting the activity of intestinal stem cells: involvement of Wnt/β-catenin signaling. CellPress：Stem Cell Research & Therapy(1). doi:10.1186/S13287-023-03293-9.
  11. Wu Zifang,Xiang Quanhang,Feng Li,Wu Deyuan,Huang Shuangbo,Zhang Longmiao... & Tan Chengquan.(2023).Adenosine-ADORA2A Promotes Ang-Induced Angiogenesis in Intrauterine Growth Restriction Placenta via the Stat3/Akt Pathway.. Arteriosclerosis, thrombosis, and vascular biology. doi:10.1161/ATVBAHA.122.318948.
  12. He Liuqin, Ding Yaqiong, Zhou Xihong,Li Tiejun & Yin Yulong.(2023).Serine signaling governs metabolic homeostasis and health.. CellPress：Trends in endocrinology and metabolism: TEM(6). doi:10.1016/J.TEM.2023.03.001.
  13. Jian Fu, Ziyi Han, Zebiao Wu, Yaoyao Xia.Guan Yang, Yulong Yin, Wenkai Ren. GABA regulates IL-1 production in macrophages, CellPress：Cell Reports (2022), htps://doi.org/10.1016/j.celrep.2022.111770
  14. Jingxia Gao,Zhe Yang,Chongqi Zhao,Xiongzhuo Tang,Qian Jiang & Yulong Yin.(2023). A comprehensive review on natural phenolic compounds as alternatives to in-feed antibiotics. Science China (Life Sciences)(07),1518-1534.
  15. Zhang L , Liu C , Jiang Q ,et al.Butyrate in Energy Metabolism: There Is Still More to Learn. CellPress：Trends in Endocrinology and Metabolism, 2021, 32(3).DOI:10.1016/j.tem.2020.12.003.
  16. Melatonin signaling in T cells: Functions and applications / Ren, WK (Ren, Wenkai); Liu, G (Liu, Gang); Chen, S (Chen, Shuai); Yin, J (Yin, Jie); Wang, J (Wang, Jing); Tan, B (Tan, Bie); Wu, G (Wu, Guoyao); Bazer, FW (Bazer, Fuller W.); Peng, YY (Peng, Yuanyi); Li, TJ (Li, Tiejun); Reiter, RJ (Reiter, Russel J.); Yin, YL (Yin, Yulong) / JOURNAL OF PINEAL RESEARCH62(3): e12394 DOI: 10.1111/jpi.12394 / APR 2017
  17. Environmental Sustainability Analysis and Nutritional Strategies of Animal Production in China / Tan, B (Tan, Bie); Yin, YL(Yin, Yulong) Annual review of animal biosciences, 5:171-184(2017). 
  18. Chen S, Wu X, Xia Y, Wang M, Liao S, Li F, Yin J, Ren W, Tan B, Yin Y. Effects of dietary gamma-aminobutyric acid supplementation on amino acid profile, intestinal immunity, and microbiota in ETEC-challenged piglets. Food Funct. 2020 Oct 21;11(10):9067-9074. doi: 10.1039/d0fo01729a. PMID: 33025994. 
  19. Mou Q, Yang HS, Yin YL, Huang PF. Amino Acids Influencing Intestinal Development and Health of the Piglets. Animals (Basel). 2019 May 31;9(6):302. doi: 10.3390/ani9060302. PMID: 31159180; PMCID: PMC6617173. 
  20. Xia Y, Chen S, Zhao Y, Chen S, Huang R, Zhu G, Yin Y, Ren W, Deng J. GABA attenuates ETEC-induced intestinal epithelial cell apoptosis involving GABAAR signaling and the AMPK-autophagy pathway. Food Funct. 2019 Nov 1;10(11):7509-7522. 
  21. Wu G, Bazer FW, Davis TA, Kim SW, Li P, Marc Rhoads J, Carey Satterfield M, Smith SB, Spencer TE, Yin Y. Arginine metabolism and nutrition in growth, health and disease. Amino Acids. 2009 May;37(1):153-68. doi: 10.1007/s00726-008-0210-y. Epub 2008 Nov 23. PMID: 19030957; PMCID: PMC2677116. 
  22. Ren W, Bin P, Yin Y, Wu G. Impacts of Amino Acids on the Intestinal Defensive System. Adv Exp Med Biol. 2020;1265:133-151. doi: 10.1007/978-3-030-45328-2_8. PMID: 32761574. 
  23. 11、Hussain T, Tan B, Murtaza G, Metwally E, Yang H, Kalhoro MS, Kalhoro DH, Chughtai MI, Yin Y. Role of Dietary Amino Acids and Nutrient Sensing System in Pregnancy Associated Disorders. Front Pharmacol. 2020 Dec 22;11:586979. doi: 10.3389/fphar.2020.586979. PMID: 33414718; PMCID: PMC7783402. 
  24. Xia Y, Chen S, Zeng S, Zhao Y, Zhu C, Deng B, Zhu G, Yin Y, Wang W, Hardeland R, Ren W. Melatonin in macrophage biology: Current understanding and future perspectives. J Pineal Res. 2019 Mar;66(2):e12547. doi: 10.1111/jpi.12547. Epub 2019 Jan 21. PMID: 30597604. 
  25. He F, Wu C, Li P, Li N, Zhang D, Zhu Q, Ren W, Peng Y. Functions and Signaling Pathways of Amino Acids in Intestinal Inflammation. Biomed Res Int. 2018 Feb 26;2018:9171905. doi: 10.1155/2018/9171905. PMID: 29682569; PMCID: PMC5846438. 
  26. Yang G, Xia Y, Ren W. Glutamine metabolism in Th17/Treg cell fate: applications in Th17 cell-associated diseases. Sci China Life Sci. 2021 Feb;64(2):221-233. doi: 10.1007/s11427-020-1703-2. Epub 2020 Jul 13. PMID: 32671630. 
  27. He F, Yin Z, Wu C, Xia Y, Wu M, Li P, Zhang H, Yin Y, Li N, Zhu G, Ren W, Peng Y. l-Serine Lowers the Inflammatory Responses during Pasteurella multocida Infection. Infect Immun. 2019 Nov 18;87(12):e00677-19. doi: 10.1128/IAI.00677-19. PMID: 31570555; PMCID: PMC6867830. 
  28. Chen S, Xia Y, He F, Fu J, Xin Z, Deng B, He L, Zhou X, Ren W. Serine Supports IL-1β Production in Macrophages Through mTOR Signaling. Front Immunol. 2020 Aug 27;11:1866. doi: 10.3389/fimmu.2020.01866. PMID: 32973770; PMCID: PMC7481448. 
  29. Chen S , Tan B , Xia Y , Liao S , Wang M , Yin J , Wang J , Xiao H , Qi M , Bin P , Liu G , Ren W , Yin Y. Effects of dietary gamma-aminobutyric acid supplementation on the intestinal functions in weaning piglets. Food Funct. 2019 Jan 22;10(1):366-378. doi: 10.1039/c8fo02161a. PMID: 30601517. 
  30. Ren W, Rajendran R, Zhao Y, Tan B, Wu G, Bazer FW, Zhu G, Peng Y, Huang X, Deng J, Yin Y. Amino Acids As Mediators of Metabolic Cross Talk between Host and Pathogen. Front Immunol. 2018 Feb 27;9:319. doi: 10.3389/fimmu.2018.00319. PMID: 29535717; PMCID: PMC5835074. 
  31. Ren W, Wang K, Yin J, Chen S, Liu G, Tan B, Wu G, Bazer FW, Peng Y, Yin Y. Glutamine-Induced Secretion of Intestinal Secretory Immunoglobulin A: A Mechanistic Perspective. Front Immunol. 2016 Nov 24;7:503. doi: 10.3389/fimmu.2016.00503. PMID: 27933057; PMCID: PMC5121228. 
  32. Wu M, Xiao H, Liu G, Chen S, Tan B, Ren W, Bazer FW, Wu G, Yin Y. Glutamine promotes intestinal SIgA secretion through intestinal microbiota and IL-13. Mol Nutr Food Res. 2016 Jul;60(7):1637-48. doi: 10.1002/mnfr.201600026. Epub 2016 Apr 24. PMID: 27005687. 
  33. Zheng C, Song B, Duan Y, Zhong Y, Yan Z, Zhang S, Li F. Dietary β-hydroxy-β-methylbutyrate improves intestinal function in weaned piglets after lipopolysaccharide challenge. Nutrition. 2020 Oct;78:110839. doi: 10.1016/j.nut.2020.110839. Epub 2020 Apr 21. PMID: 32540677. 
  34. Hu C, Li F, Duan Y, Yin Y, Kong X. Dietary Supplementation With Leucine or in Combination With Arginine Decreases Body Fat Weight and Alters Gut Microbiota Composition in Finishing Pigs. Front Microbiol. 2019 Aug 13;10:1767. doi: 10.3389/fmicb.2019.01767. PMID: 31456756; PMCID: PMC6700229. 
  35. Duan Y, Tan B, Li J, Liao P, Huang B, Li F, Xiao H, Liu Y, Yin Y. Optimal branched-chain amino acid ratio improves cell proliferation and protein metabolism of porcine enterocytesin in vivo and in vitro. Nutrition. 2018 Oct;54:173-181. doi: 10.1016/j.nut.2018.03.057. Epub 2018 Apr 24. PMID: 30048883. 
  36. Duan Y, Zeng L, Li F, Wang W, Li Y, Guo Q, Ji Y, Tan B, Yin Y. Effect of branched-chain amino acid ratio on the proliferation, differentiation, and expression levels of key regulators involved in protein metabolism of myocytes. Nutrition. 2017 Apr;36:8-16. doi: 10.1016/j.nut.2016.10.016. Epub 2016 Nov 22. PMID: 28336113. 
  37. Duan Y, Duan Y, Li F, Li Y, Guo Q, Ji Y, Tan B, Li T, Yin Y. Effects of supplementation with branched-chain amino acids to low-protein diets on expression of genes related to lipid metabolism in skeletal muscle of growing pigs. Amino Acids. 2016 Sep;48(9):2131-44. doi: 10.1007/s00726-016-2223-2. Epub 2016 May 7. PMID: 27156063. 
  38. Wang J, Tan B, Li J, Kong X, Tan M, Wu G, Regulatory role of L-proline in fetal pig growth and intestinal epithelial cell proliferation, Animal Nutrition, 2020,6:438-446. 
  39. Xiao H, Zha C, Shao F, Wang L, Tan B. Amino acids regulate energy utilization through mammalian target of rapamycin complex 1 and adenosine monophosphate activated protein kinase pathway in porcine enterocytes, Animal Nutrition, 2020, 6(1):98-106. 
  40. Qi M, Tan B, Wang J, Li J, Liao S, Yan J, Liu Y, Yin Y. Small intestinal transcriptome analysis revealed changes of genes involved in nutrition metabolism and immune responses in growth retardation piglets. Journal of Animal Science, 2019, 97:3795–3808 
  41. Liu H, Tan B, Huang B, Li J, Wang J, Liao P, Guan G, Ji P, Yin Y*. Involvement of CaSR activation in the alleviation of intestinal inflammation in piglets model by dietary aromatic amino acid supplementation. British Journal of Nutrition, 2018, 120(12):1321-1331. 
  42. Tan BE, Liu HL, He GZ, Xiao H, Xiao DF, Liu YH, Wu JP, Fang J, Yin YL. Alanyl-glutamine but not glycyl-glutamine improves the proliferation of enterocytes as glutamine substitution in vitro. Amino Acids, 2017, 49(12):2023-2031 
  43. Wang J, Tan BE, Li GR, Xiao H, Huang B, Zhang MH, Yin YL. Polyamine metabolism in the intestine of piglets is altered by weaning and proline supplementation. Journal of Animal Science, 2016, 94:423–428 
  44. Tan BE, Xiao H, Xiong X, Wang J, Li GR, Yin YL, Huang B, Hou YQ, Wu GY. L-Arginine improves DNA synthesis in LPS-challenged enterocytes. Frontiers in Bioscience, 2015, 20: 989-1003 
  45. Wang J, Li GR, Tan BE, Xiong X, Kong XF, Xiao DF, Xu LW, Wu MM, Huang B, Kim SW, Yin YL. Oral administration of putrescine and proline during the suckling period improve epithelial restitution after early weaning in piglets. Journal of Animal Science, 2015, 93(4): 1679-1688 
  46. Xiao H, Wu MM, Shao FY, Huang B, Tan BE, Yin YL. N-acetyl-L-cysteine (NAC) protects the enterocyte against oxidative damage by preserving mitochondrial function. Amino Acids, 2015, 47(8): 1681-1681 
  47. Tan BE, Yin YL, Kong XF, Li P, Li XL, Gao HJ, Li XG, Huang RL, Wu GY. L-Arginine stimulates proliferation and prevents endotoxin-induced death of intestinal cells. Amino Acids, 2010, 38: 1227-1235. 
  48. Tan BE, Li XG, Kong XF, Huang RL, Ruan Z, Yao K, Deng ZY, Xie MY, Shinzato I, Yin YL, Wu GY. Dietary L-arginine supplementation enhances the immune status in early-weaned piglets. Amino Acids, 2009, 37:323-331. 
  49. Liuqin He#, Li Wu#, Zhiqi Xu, Tiejun Li*, Kang Yao*, Zhijie Cui, Yulong Yin, Guoyao Wu. Low-protein diets affect ileal amino acid digestibility and gene expression of digestive enzymes in growing and finishing pigs. Amino Acids. 2016 Jan;48(1):21-30. 
  50. Liuqin He, Huan Li, Niu Huang, Junquan Tian, Zhiqiang Liu, Xihong Zhou*, Kang Yao*, Tiejun Li*, Yulong Yin. Effects of Alpha-Ketoglutarate on Glutamine Metabolism in Piglet Enterocytes in Vivo and in Vitro. J Agric Food Chem. 2016 Apr 6;64(13):2668-73. 
  51. Liuqin He, Niu Huang, Huan Li, Zhiqi Xu, Kang Yao*, Tiejun Li*, Yulong Yin*. Effects of dietary L-lysine supplementation on lysine transport by the piglet small intestine in vitro. J. Anim. Sci. 2016.94:106–110 
  52. Liuqin He, Huan Li, Niu Huang, Xihong Zhou, Junquan Tian, Yanan Tian, Jing Wu, Yulong Yin*, Kang Yao*. Alpha-ketoglutarate suppresses the NF-κB-mediated inflammatory pathway and enhances the PXR-regulated detoxification pathway. Oncotarget. 2017 Apr 6;8(61):102974-102988. 
  53. Liuqin He#, Xihong Zhou#, Niu Huang, Huan Li, Zhijie Cui, Junquan Tian, Qian Jiang, Shaojian Liu, Jian Wu, Tiejun Li, Kang Yao*, Yulong Yin*. Administration of alpha-ketoglutarate improves epithelial restitution under stress injury in early-weaning piglets. Oncotarget. 2017 Aug 24;8(54):91965-91978. 
  54. Liuqin He, Jian Wu, Wenjie Tang, Xihong Zhou*, Qinlu Lin, Feijun Luo, Yulong Yin, Tiejun Li*. Prevention of Oxidative Stress by α-Ketoglutarate via Activation of CAR Signaling and Modulation of the Expression of Key Antioxidant-Associated Targets in Vivo and in Vitro. J Agric Food Chem. 2018 Oct 31;66(43):11273-11283. 
  55. Xihong Zhou#, Liuqin He#, Cairong Wu, Yiming Zhang, Xin Wu*, Yulong Yin. Serine alleviates oxidative stress via supporting glutathione synthesis and methionine cycle in mice. Mol Nutr Food Res. 2017 Nov;61(11). 
  56. Liuqin He, Haiwen Zhang, Xihong Zhou*. Weanling Offspring of Dams Maintained on Serine-Deficient Diet Are Vulnerable to Oxidative Stress. Oxid Med Cell Longev. 2018 Sep 16; 2018:8026496. 
  57. Wenjie Tang#, Jian Wu#, Shunshun Jin, Liuqin He*, Qinlu Lin, Feijun Luo, Xingguo He, Yanzhong Feng, Binsheng He, Pingping Bing, Tiejun Li*, Yinlong Yin. Glutamate and aspartate alleviate testicular/epididymal oxidative stress by supporting antioxidant enzymes and immune defense systems in boars. Sci China Life Sci. 2020 Jan;63(1):116-124. 
  58. Liuqin He, Jing Long, Xihong Zhou*, Yonghui Liu, Tiejun Li, Xin Wu. Serine is required for the maintenance of redox balance and proliferation in the intestine under oxidative stress. FASEB J. 2020 Mar; 34(3):4702-4717. 
  59. Liuqin He, Yonghui Liu, Jing Long, Xihong Zhou*, Sijing Zeng, Tiejun Li*, Yulong Yin. Maternal serine supply from late pregnancy to lactation improves offspring performance through modulation of metabolic pathways. Food Funct. 2020 Sep 23;11(9):8089-8098. 
  60. Zhai Z, Boquete J-P, Lemaitre B. Cell-Specific Imd-NF-κB Responses Enable Simultaneous Antibacterial Immunity and Intestinal Epithelial Cell Shedding upon Bacterial Infection. Immunity (2018) 48(5):798-910. doi: 10.1016/j.immuni.2018.04.010 
  61. Zhai Z, Huang X, Yin Y. Beyond immunity: The Imd pathway as a coordinator of host defense, organismal physiology and behavior. Developmental and Comparative Immunology (2018) 83:51-59. doi: 10.1016/j.dci.2017.11.008 
  62. Ren W, Wu M, Luo W, Huang R, Yin Y, Li Y, Li T, Yu X. Dietary supplementation with proline confers a positive effect in both porcine circovirus-infected pregnant and non-pregnant mice. Br J Nutr. 2013 Oct;110(8):1492-9. 
  63. Ren W, Luo W, Wu M, Liu G, Yu X, Fang J, Li T, Yin Y, Wu G. Dietary L-glutamine supplementation improves pregnancy outcome in mice infected with type-2 porcine circovirus. Amino Acids. 2013 Sep;45(3):479-88. 
  64. Ren W, Yin Y, Liu G, Yu X, Li Y, Yang G, Li T, Wu G. Effect of dietary arginine supplementation on reproductive performance of mice with porcine circovirus type 2 infection. Amino Acids. 2012 Jun;42(6):2089-94. 
  65. Ren W, Chen S, Yin J, Duan J, Li T, Liu G, Feng Z, Tan B, Yin Y, Wu G. Dietary arginine supplementation of mice alters the microbial population and activates intestinal innate immunity. J Nutr. 2014 Jun;144(6):988-95. 
  66. Ren W, Yin J, Duan J, Liu G, Tan B, Yang G, Wu G, Bazer FW, Peng Y, Yin Y. mTORC1 signaling and IL-17 expression: Defining pathways and possible therapeutic targets. Eur J Immunol. 2016 Feb;46(2):291-9. 
  67. Ren W, Yin J, Xiao H, Chen S, Liu G, Tan B, Li N, Peng Y, Li T, Zeng B, Li W, Wei H, Yin Z, Wu G, Hardwidge PR, Yin Y. Intestinal Microbiota-Derived GABA Mediates Interleukin-17 Expression during Enterotoxigenic Escherichia coli Infection. Front Immunol. 2017 Jan 16;7:685. 
  68. Ren W, Liao Y, Ding X, Jiang Y, Yan J, Xia Y, Tan B, Lin Z, Duan J, Jia X, Yang G, Deng J, Zhu C, Hardwidge PR, Li J, Zhu G, Yin Y. Slc6a13 deficiency promotes Th17 responses during intestinal bacterial infection. Mucosal Immunol. 2019 Mar;12(2):531-544. 
  69. Zhao Y, Wang J, Wang H, Huang Y, Qi M, Liao S, Bin P, Yin Y. Effects of GABA Supplementation on Intestinal SIgA Secretion and Gut Microbiota in the Healthy and ETEC-Infected Weanling Piglets. Mediators Inflamm. 2020 May 26;2020:7368483. 
  70. Dun Deng 1, Kang Yao, Wuying Chu, Tiejun Li, Ruiling Huang, Yulong Yin, Zhiqiang Liu, Jianshe Zhang, Guoyao Wu. Impaired translation initiation activation and reduced protein synthesis in weaned piglets fed a low-protein diet. J Nutr Biochem. 2009 Jul;20(7):544-52. 
  71. Jiang Q, Chen J, Liu S, Liu G*, Yao K*, Yin Y. l-Glutamine Attenuates Apoptosis Induced by Endoplasmic Reticulum Stress by Activating the IRE1α-XBP1 Axis in IPEC-J2: A Novel Mechanism of l-Glutamine in Promoting Intestinal Health. International Journal of Molecular Sciences. (2017) 18(12):2617. 
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