snRNA-Seq and Spatial Transcriptome Reveal Muscle-Adipose Tissue Crosstalk in Porcine Skeletal Muscle
A new study led by Prof. Yin Yulong from the Institute of Subtropical Agriculture, Chinese Academy of Sciences, conducted integrated snRNA-seq and spatial transcriptome analysis of the longissimus dorsi (LD) muscle between TB and Duroc pigs at 180 days, which revealed a discrepancy in the expression profile between TB and Duroc pigs with cellular heterogeneity and spatial specificity. This study, published in Journal of Cachexia, Sarcopenia and Muscle on March 13, highlights important contribution to metabolic regulation of interaction between various cell populations in skeletal muscle and provides potential secretory genes to be diagnostic and intervention targets for metabolic diseases in humans and meat quality in pigs. Guo Liu serves as the first author of this paper, while Prof. Li Fengna and Yin Yulong are the corresponding authors.
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