Xin Wu, PhD, full professor, supervisor of PhD and master student of University of Chinese Academy of Sciences, Nanchang University and Hunan Agriculture University. He was born in Henan Province in 1979, received his Ph.D degree from Institute of Subtropical Agriculture, the Chinese Academy of Sciences in 2010. Now, he is a full professor of Institute of Subtropical Agriculture, CAS.

Undertaking several national projects mainly on amino acids metabolism, such as the National Natural Science Funds, the STS Program of Chinese Academy of Sciences, CAS President’s International Fellowship for Visiting Scientists, and Hunan Natural Science Fund. Based on these research grants, he got 29 patents, and has published more than 200 papers.

Professional affiliations: Vice President of Traditional Chinese Medicine and Agriculture Branch, World Federation of Chinese Medicine Societies (WFCMS), Vice President of Aromatic Health Industry Branch, World Federation of Chinese Medicine Societies (WFCMS), Secretary-general of the Trace Element and Food Chain Society (TEFCS) of the China Association of Agricultural Science Societies (CAASS).

Research interests: nutrition metabolism including amino acids, nucleotide and mineral with the physiological functions to the well-being of animals and people; nutrition and circadian clock; maternal nutrition.

Welcome international students to join our group.

2018.12- Full professor, Institute of Subtropical Agriculture Chinese Academy of Sciences, Changsha, China;

2020.01-04, visiting scholar, Erasmus MC, Erasmus University Rotterdam, The Netherlands;

2012.11-2018.12 Associate professor, Institute of Subtropical Agriculture Chinese Academy of Sciences, Changsha, China;

2013.05-2014.05 Visiting scholar, INRA, AgroParisTech, Paris, France;

2010.10-2013.05, Postdoc, Nanchang University, Nanchang, China

2010.07-2012.11Assistant professor, Institute of Subtropical Agriculture Chinese Academy of Sciences, Changsha, China;

2005.09-2010.07, Doctor Degree of Ecology (Animal nutrition), Institute of Subtropical Agriculture, the Chinese Academy of Sciences, Changsha, China;

2005.09-2006.07, the Graduate University of Chinese Academy of Sciences, Beijing, China;

Graduation: 2001.09-2005.07, Bachelor degree of Animal Science, Huazhong Agricultural University, Wuhan, China;

1.Meng Ru, Wanwan Wang, Zhenya Zhai, Ruxia Wang, Yumeng Li, Jiang Liang, Damini Kothari, Kai-Min Niu*, Xin Wu*. Nicotinamide mononucleotide supplementation protects the intestinal function in aging mice and D-galactose induced senescent cells. Food & Function, 2022, Doi: 10.1039/D2FO00525E

2.Teketay Wassie, Xinyi Duan, Chunyan Xie, Ruxia Wang, Xin Wu*. Dietary Enteromorpha polysaccharide-Zn supplementation regulates amino acid and fatty acid metabolism by improving the antioxidant activity in chicken. Journal of Animal Science and Biotechnology, 2022, 13: 18

3.Gao Le*, Dongyuan Zhang, Xin Wu*. In-situ corn fiber conversion for ethanol improvement by the addition of novel lignocellulolytic enzyme cocktail. Journal of fungi, 2022, 8: 221

4.Yingying Feng, Teketay Wassie, Renyou Gan*, Xin Wu*. Structural Characteristics and Immunomodulatory Effects of Sulfated Polysaccharides Derived from Marine Algae. Critical Reviews in Food Science and Nutrition, 2022, DOI: 10.1080/10408398.2022.2043823

5.Yumei Zhang, Xinyi Duan, Teketay Wassie, Hai-hua Wang, Tiejun Li, Chunyan Xie*, Xin Wu. Enteromorpha prolifera polysaccharide-zinc complex modulates immune response and alleviates LPS-induced intestinal inflammation via inhibiting the TLR4/NF-??B signaling pathway. Food & Function, 2022, 13, 52–63

6.Guokun Wang*, Xin Wu*, Yulong Yin*. Synthetic biology-driven customization of functional feed resources. Trends in Biotechnology, 2022, Doi: 10.1016/j.tibtech.2022.03.002

7.Niu KM, Tongtong Bao, Lumin Gao, Meng Ru, Yumeng Li, Liang Jiang, Changming Ye, Shujin Wang, Xin Wu*. Short-term NMN supplementation on impacts of serum metabolism, fecal microbiota, and telomere length in pre-aging phase. Frontiers in Nutrition, 2021, 8:756243

8.Gao L., Liu Y., Zhou X., Zhang Y., Wu X.*, Yin Y. Maternal supplementation with uridine influences fatty acids and amino acids constituents of offspring in a sow-piglet model. British Journal of Nutrition, 2021, 125: 743-756

9.Teketay Wassie, Zhuang Lu, Xinyi Duan, Chunyan Xie, Kefyalew Gebeyew, Zhang Yumei, Yulong Yin and Wu Xin*. Dietary Enteromorpha polysaccharide enhances intestinal immune response and barrier function of broiler chickens via modulating gut microbiota. Frontiers in Nutrition, 2021, 8:783819

10.Chunyan Xie, Yumei Zhang, Kaimin Niu, Xiaoxiao Liang, Haihua Wang, Junwei Shan, Xin Wu*. Enteromorpha polysaccharide-zinc replacing prophylactic antibiotics contributes to improving gut health of weaned piglets. Animal Nutrition, 2021, 7(3): 641-649

11.Yi-lin Liu, Chun-yan Xie, Zeyuan Deng, Xin Wu*, Ruan Zheng*. Uridine attenuates obesity, ameliorates hepatic lipid accumulation and modifies the gut microbiota composition in mice fed a high-fat diet. Food & Function, 2021, 12: 1829-1840

12.Lumin Gao, Chun-yan Xie, Xiao-xiao Liang, Zhi-hong Li, Biao Li, Xin Wu*, Yu-long Yin. Maternal yeast-based nucleotides supplementation modifies intestinal barrier function and immune response of neonatal pigs. Animal Nutrition, 2021, 7(1): 84-93

13.Teketay Wassie, Kaimin Niu, Chunyan Xie, Haihua Wang and Xin Wu*. Extraction Techniques, Biological Activities and Health Benefits of Marine Algae Enteromorpha prolifera polysaccharide. Frontiers in Nutrition, 2021, 8: 747928, DOI: 10.3389/fnut.2021.747928

14.Zhenya Zhai, Kaimin Niu, Yichun Liu,Chong Lin, Xin Wu*. The gut microbiota-bile acids-TGR5 Axis mediates Eucommia ulmoides leaf extract alleviation of injury to colonic epithelium integrity. Frontiers in Microbiology, 2021, 12:2168

15.Tian-Tian Meng, Lumin Gao, Chun-yan XIE, Yangkui Xiang, Yi-qiang Huang, Ya-wei Zhang, Xin Wu*. Manganese Methionine Hydroxy Analog Chelated Affects Growth Performance, Trace Element Deposition and Expression of Related Transporters of Broilers. Animal Nutrition, 2021, 7(2): 481-487.

16.Zhenglin Dong, Lan Li, Yiming Zhang, Liu Guo, Xin Wu*, Yulong Yin, Dan Wan*. Effects of circadian iron administration on iron bioavailability and biological rhythm in pigs. Journal of the Science of Food and Agriculture, 2021, 101: 2712–2717

17.Shuai ZHANG, Xin Wu, Dandan HAN, Yong HOU, Jianzhuang TAN, Sung Woo KIM, Defa LI, Yulong YIN, Junjun WANG. Pork production systems in China: a review of their development, challenges and prospects in green production. Frontiers of Agricultural Science and Engineering, 2021, 8(1): 15–24

18.Gao LM, TT Zhou, ZP Chen, Teketay Wassie, B Li, WU X*, YL Yin. Maternal yeast-based nucleotides supplementation decreased stillbirth by regulating nutrient metabolism. Journal of the Science of Food and Agriculture, 2021, 101(10): 4018-4032.

19.Tian-Tian Meng，Xue Lin，Chun-Yan Xie*，Jian-Hua He，Xin Wu. Nanoselenium and Selenium Yeast Have Minimal Differences on Egg Production and Se Deposition in Laying Hens. Biological Trace Element Research, 2021, 199:2295-2302

20.Xue LIN, Tiantian MENG, Ting YANG, Xiang XU, Yurong ZHAO*, Xin Wu*. Circadian zinc feeding regime in laying hens related to laying performance, oxidation status, interaction of zinc and calcium. Poultry Science, 2020, ?99:6783–6796

21.Dan Wan, Yikun Li, Guanya Li, Xin Wu*, Dongming Zhang, Xugang Shu. Dietary supplementation with N-carbamylglycinate (CGly) improved feed source proline absorption and reproductive performance in sows. Food & Function, 2020, 11, 3126-3133

22.Xin Wu, Lu-min Gao, Yi-lin Liu, Chunyan Xie, Lichuang Cai, Kang Xu, Xi-hong Zhou. Maternal dietary uridine supplementation reduces diarrhea incidence in piglets by regulating the intestinal mucosal barrier and cytokine profiles. Journal of the Science of Food and Agriculture, 2020, 100(9): 3709-3718

23.Chunyan Xie, Xinyi Duan, Cimin Long, Xin Wu*. Hepatic lipid metabolism is affected by daily 3-meal pattern with varying dietary crude protein with a pig model. Animal nutrition, 2020, 6: 16-23

24.Y. Liu, S. Guo, C. Xie, K. Niu, H. De Jonge, X. Wu*. Uridine inhibits stemness of intestinal stem cells via mTOR in 3D intestinal organoids and mice. RSC Advances, 2020, 10(11): 6377-6387

25.C. Xie, Q. Wang, G. Li, Z. Fan, H. Wang, X. Wu *. Dietary supplement with nucleotides in the form of uridine monophosphate or uridine stimulate the intestinal development and promote nucleotide transport in weaned piglets. J Sci Food Agri, 2019, 99: 6108–6113

26.Y. Liu, Y. Zhang, J. Yin, X. Zhou, X. Wu*, Y. Yin, Z. Ruan*. Uridine dynamic administration affects circadian variations in lipid metabolisms in the liver of high-fat diet-fed mice. Chron Inter, 2019, 36:9, 1258-1267

27.G. Li, C. Xie, Q. Wang, D. Wan*, X. Wu*, Y. Yin. Uridine/UMP metabolism and their function on the gut in segregated early weaned piglets. Food & Function, 2019, 10, 4081-4089

28.Y. Yin, H. R. de Jonge, X. Wu*, Y. Yin. Mini-gut: a promising model for drug development. Drug Discovery Today, 2019, 24(9):1784-1794

29.L. Qin, W. Ji, J. Wang, B. Li, J. Hu*, X. Wu*. Dietary supplementation with yeast glycoprotein or antibiotics have different effects on growth performance, intestinal mucosal morphology, immune response and colonic microbiome in weaned piglets. Food & Function, 2019, 10: 2359-2371

30.Liu Y., Wan D., X. Zhou, R. Zheng, X. Wu*, Yulong Yin. Dynamic feeding of methionine rhythmically influences glucose and lipid metabolism in the liver of laying hens. Poultry Science, 2019, 98:2231–2240

31.Y. Yin, De Jonge HR, Xin Wu*, and Yulong Yin. Enteroids for nutritional studies. Molecular Nutrition & Food Research. 2019, 18: e1801143

33.X. Wu*, C. Xie, C. Long, J. Li, X. Zhou, Z. Fan, F. Blachier, Y. Yin*. Effects of a daily 3-meal pattern with different dietary protein contents on pig growth performance, carcass and muscle quality traits. J Sci Food Agri, 2018, 98(1): 415-421

34.Yin J., Y. Li, H. Han, S. Chen, J. Gao, G. Liu, X. Wu*, J. Deng, X. Huang, R. Fang, T. Li*, R. J. Reiter, G. Zhu, W. Ren*, Y. Yin. Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high fat diet-fed mice. Journal of Pineal Research, 2018:e12524

35.X. Wu, L. Gao, K. Zhou, X. Li, X. Lin, D. Wan, X. Xiong, G. Liu, Y. Yin*. Deposition and transport of trace mineral elements were affected by stocking density in fattening pigs. J Trace Elem Med Biol, 2018, 50：566-571

36.X. Lin, Y. Liu, T. Meng, C. Xie, X. Wu*, Y. Yin. Circadian calcium feeding regime in laying hens related to zinc concentration, gene expression of circadian clock, calcium transporters and oxidative status. J Trace Elem Med Biol, 2018, 50：518-526

37.X. Zhou, H. Zhang, L. He, X. Wu*, Y. Yin. Long-term L-serine administration reduces food intake and improves oxidative stress and Sirt1/NFκB pathway in the hypothalamus in aging mice. Frontiers in Endocrinology, 2018,9:476

38.D. Wan, Y. M. Zhang, X. Wu*, X. Lin, X. G. Shu, X. H. Zhou, W.G. Xing, H. N. Liu, L. Li, Y. Li, H. T. Du, Yulong Yin*. Maternal dietary supplementation with ferrous N-carbamylglycinate chelate affects sow reproductive performance and iron status of neonatal piglets. Animal, 2018, 12(7):1372-1379

39.X. Zhou, L. He, S. Zuo, Y. Zhang, C. Long, P. Huang, C. Wu, G. Liu, X. Wu *, Y. Yin*. Serine attenuates high-fat diet-induced oxidative stress by activating AMPK and epigenetically modulating the expression of glutathione synthesis-related genes. BBA-Molecular Basis of Disease, 2018, 1864：488–498

40.Wu X., C. Xie, X. Guo, C. Long, T. Zhang, T. Gao, Y. Yin*. A Maternal meal Feeding Pattern with Varying Crude Protein Affacted Milk Lipid Profile in A Sow-Piglet Model. Scientific Reports, 2017, 7: 13742

41.X. Zhou, L. He, C. Wu, Y. Zhang, X. Wu*, Y. Yin. Serine alleviates oxidative stress via supporting glutathione synthesis and methionine cycle in mice. Molecular Nutrition & Food Research, 2017, 61(11)：1700262

42.Liu Y., Lin X., Zhou X., Wan D., Wu X.*, Yin Y. Effects of dynamic feeding low and high methionine diets on egg quality traits in laying hens. Poultry Science, 2017, 96(5): 1459-1465

43.C. Xie, X. Wu*, C. Long, Q. Wang, Z. Fan, S. Li, Y. Yin*. Chitosan oligosaccharide affects antioxidant defense capacity and placental amino acids transport of sows. BMC Veterinary Research, 2016 12:243

44.B. Li, H. Zhou, X. Wu*, Z. Chen, J. Yao, Y. Yin*. Effects of dietary supplementation with uridine monophosphate on performance and intestinal morphology of weanling piglets. J Anim Sci, 2016, 94:82–86

45.C. Xie, C. Long, X. Wu*, Z., Y. Wang, Y. Yin*. Effect of maternal supplementation with chitosan oligosaccharide on the antioxidant capacity in suckling piglets. J Anim Sci, 2016, 94: 453-456.

46.Wu X., Wan D., Xie C., Li T., Huang R., Shu X., Ruan Z., Deng Z., Yin Y.. Acute and sub-acute oral toxicological evaluations and mutagenicity of N-carbamylglutamate (NCG). Regul Toxicol Pharm, 2015, 73 (1):296-302.

47.Xie C., Guo X., Long C., Fan Z., Ruan Z., Deng Z., Xiao D., Wu X.*, Yin Y.*. Supplementation of the sow diet with chitosan oligosaccharide during late gestation and lactation affects hepatic gluconeogenesis of suckling piglets. Anim Reprod Sci, 2015, 159：109-117

48.Wan D., Zhou, X. Xie, C., Shu X., Wu X.*, Yin Y.*. Toxicological Evaluation of Ferrous N-carbamylglycinate Chelate: Acute, Sun-acute toxicity and Mutagenicity. Regul Toxicol Pharm. 2015, 73, (2): 644–651

49.X. Wu, Y. Zhang, Y. Yin, G. Wu. Role of stress protein 70 in protecting against intestinal mucosal damage. FRONTIERS IN BIOSCIENCE, 2013, 18, 356-365

50.X. Wu, C. Xie, Y. Yin, F. Li, T. Li, R. Huang, Z. Deng. Effect of L-arginine on HSP70 expression in liver in weanling piglets. BMC Veterinary Research, 2013, 9:63.

51.X. Zhou, X. Wu*, Y.L. Yin*, C Zhang, L He. Preventive oral supplementation with glutamine and arginine has beneficial effects on the intestinal mucosa and inflammatory cytokines in endotoxemic rats. Amino Acids, 2012, 43(2): 813-821.

52.X. Wu, Y.L. Yin, Y. Q. Liu, X.D. Liu, Z. Q. Liu, T.J. Li, R.L. Huang, Z. Ruan, and Z.Y. Deng. Effect of dietary arginine and N-carbamoylglutamate supplementation on reproduction and gene expression of eNOS, VEGFA and PlGF1 in placenta in late pregnancy of sows. Anim Reprod Sci, 2012 ,132:187-192

53.X. Wu, Y. Zhang, Z. Liu, T. Li, Y. Yin. Effects of oral supplementation with glutamate or combination of glutamate and N-carbamylglutamate on intestinal mucosa in piglets. J Anim Sci, 2012, 90: 337–339

54.X.D. Liu, X. Wu*, Y.L. Yin*, Y.Q. Liu, M.M. Geng, H.S. Yang, Z. Ruan, R.L. Huang, G.Y. Wu. Effects of dietary L-arginine or N-carbamylglutamate supplementation during late gestation of sows on the miR-15b/16, miR-221/222, VEGFA and eNOS expression in umbilical vein. Amino Acids, 2012, 42(6): 2111-2119.

55.Wu X, Ruan Z, Gao Y, Yin Y, Zhou X, et al. Dietary supplementation with L-arginine and N-carbamylglutamate enhances intestinal growth and heat shock protein 70 expression in weanling pigs fed a corn- and soybean meal-based diet. Amino Acids, 2010, 39: 831-839

56.Wu Xin, Yin* YL, Li TJ, Wang L, Ruan Z., Liu Z, Hou YQ. Different levels of protein on expression of L-Type Amino Acid Transporter-1. Animal, 2010, 4(9)：1518-1521.